I feel like working with paranoia in some way could be a great place to start! Maybe a character is constantly paranoid something will get them but it's never there, or a person/group of people are super paranoid due to a specific thing? (manipulative pastor, shared trauma, pseudo-science theory crafting, etc.)
you could also look at other pieces of media for inspiration or base parts of the story your trying to tell on real things (deep sea diving, mountain climbing, or abandoned buisnesses just to name a few)