It's honestly hard for me to pick just 1 since the 2000s had so many amazing shows (same goes with the 1990s), but if I had to choose just 1, it would be The Grim Adventures of Billy and Mandy. I grew up watching it all the time on Boomerang and currently watch it on Adult Swim's Checkered Past block on weekdays, so I definitely have some nostalgia for it in addition to enjoying the show as it is.