If you don't want to resize the image using CSS (because it will probably resize every image to match those metrics), you can change the HTML for that specific image doing something like:
<img src="http://picture.com/picture.jpg" height="200px" width="200px" alt="popup text when mouse is hovered">
The height and width modifier can either be in pixels (px) or percentage (%).
The alt modifier is optional, but will make text popup when you hold your mouse over the image.