First of all it depends on what setup and simulator you use, a good setup (with a steering that has feedback, clutch and manual transmission) and a good simulator with accurate mechanics and physics (such as Live for Speed and Assetto Corsa) could help you understand how cars react, learn theories and things like that. Obviously things change in real life, each car has its own setting, its own set-up, its own way of behaving. Once you are in the car many things will seem different,